New PDF release: Antipsychotic Trials in Schizophrenia: The CATIE Project

By T. Scott Stroup, Jeffrey A. Lieberman

ISBN-10: 0521895332

ISBN-13: 9780521895330

Antipsychotic drugs are a key remedy for schizophrenia and revenues of antipsychotic medicines procedure $20 billion in step with 12 months, with fierce advertising among the makers of the medication. The U.S. nationwide Institute of psychological wellbeing and fitness subsidized the medical Antipsychotic Trials of Intervention Effectiveness (CATIE) undertaking to supply self sufficient information regarding the comparative effectiveness of medicines. CATIE was once the biggest, longest and such a lot entire research of schizophrenia up to now. performed lower than rigorous double-blind stipulations, Antipsychotic Trials in Schizophrenia offers the definitive archival result of this landmark learn. The center of the ebook involves chapters curious about particular results that set the CATIE findings in a much broader context. additionally integrated are chapters at the layout, statistical analyses and implications for researchers, clinicians and coverage makers. Psychiatrists, psychiatric researchers, psychological future health coverage makers and people operating in pharmaceutical businesses will all locate this to be crucial studying.

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In Phase 2, participants who discontinued their assigned treatment with an SGA in Phase 1, 1A, or 1B were recommended to one of two randomized pathways based on their reason for discontinuation. The Tolerability pathway (Phase 2T) offered randomization to ziprasidone or one of the other atypical antipsychotics (olanzapine, quetiapine, or risperidone) not previously received by the patient in the study. , weight gain or EPS) were recommended to enter Phase 2T. The Efficacy pathway (Phase 2E) offered randomization to clozapine or an SGA (olanzapine, quetiapine, or risperidone) not previously received by the patient in the study.

05. 0125 for Z. At the same time, comparisons for these two groups had less power because they were based on fewer subjects due to the stratified design. In summary, the comparisons that were limited to smaller sample sizes in order to obtain unbiased treatment group comparisons also had an additional decrease in power due to adjustment for multiple treatment comparisons. 05. It should be noted that these comparisons were identified a priori as secondary and that all samples were of substantial magnitude in comparison to most other studies.

After the initial titration period using a starter pack of five capsules, the total BID dose of all blinded study medications was identical to the QD dosing schedule for each drug. Dosing for open-label medications The recommended dose range for open-label clozapine in Phases 2 and 3 was 200–600 mg QD. 5–50 mg IM every 2 weeks. The recommended dose range for aripiprazole in Phase 3 was 10–30 mg QD. Transition to study medications A cross-titration period of up to 28 days was permitted for patients who were already taking an antipsychotic at the time of study enrollment.

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Antipsychotic Trials in Schizophrenia: The CATIE Project by T. Scott Stroup, Jeffrey A. Lieberman


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